The purpose of this study was to develop clinically-compatible methods for manufacturing photoreceptor precursor cells from adult skin in a non-profit cGMP environment. These studies will enable clinical trials to test the safety and efficiency of patient-specific photoreceptor cell replacement in humans. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965859/
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.Friday, July 29, 2016 - 11:15
Monday, February 1, 2016 - 11:45
Dr. Wiley will serve as Assistant Professor at the WIVR and the Department of Ophthalmology & Visual Sciences. He will lead projects using patient-specific induced pluripotent stem cells and stem cell-derived retinal cells to investigate the pathophysiology of inherited eye diseases and develop new treatments. Luke also works with colleagues to develop gene replacement and genome editing strategies.
Monday, January 12, 2015 - 14:00
Gift from Mr. Howard Ruby enables the purchase of the photonic professional 2 photon laser photolithography system. This equipment will be used to generate clinical grade 3D scaffolds for human retinal engineering, transplantation and restoration of vision. These scaffolds will be processed in our new state of the art cGMP clean room facility, The Dezii Translation Vision Research Facility (DTVR), for clinical application.
Wednesday, November 12, 2014 - 14:00
Our most recent publication, Stem Cells as Tools for Studying the Genetics of Inherited Retinal Degenerations.
Tuesday, July 1, 2014 - 14:00
The recently dedicated Steven W. Dezii Translational Vision Research Facility located within the Wynn Institute for Vision Research is a state-of-the-art ISO Class 5/6 biomedical human research good manufacturing practice (GMP) laboratory. This facility contains an equipment room with a -85C freezer, a -30C freezer, and 1 2-8C refrigerator. There are 2 ISO Class 6 air showers with PPE gowning areas and 2 ISO Class 5 processing rooms equipped with 2 BioSpherix Isolation units and 2 centrifuges.