The intact laminar structure of a photoreceptor sheet makes it an attractive tissue for ocular transplantation.
3D Eye Cups
100μm-thick sections of 63-day iPSC-derived 3D eyecups are multilayered retinal-like structures that express PAX6 (red), MITF (green; future RPE cells) and OTX2 (magenta; future photoreceptors).
Formation of a large teratoma at 4 weeks post injection of undifferentiated iPSCs into a mouse eye.
Retinal degeneration stimulates muller cell activity and glial scar formation at the outer limits of the diseased retina.
Adult Mouse iPSCs
iPSCs generated from adult mice expressing the red fluorescent reporter dsRed.
Mitotically active fibroblast cell being reprogrammed.
Normal Mouse Retina
Mouse retina labeled with antibodies against red/green cone opsins (magenta) and rhodopsin (green).