Photoreceptor Sheets

The intact laminar structure of a photoreceptor sheet makes it an attractive tissue for ocular transplantation.
3D Eye Cups

100μm-thick sections of 63-day iPSC-derived 3D eyecups are multilayered retinal-like structures that express PAX6 (red), MITF (green; future RPE cells) and OTX2 (magenta; future photoreceptors).
Teratoma Formation

Formation of a large teratoma at 4 weeks post injection of undifferentiated iPSCs into a mouse eye.
Retinal Gliosis

Retinal degeneration stimulates muller cell activity and glial scar formation at the outer limits of the diseased retina.
Adult Mouse iPSCs

iPSCs generated from adult mice expressing the red fluorescent reporter dsRed.
iPSC Generation

Mitotically active fibroblast cell being reprogrammed.
Normal Mouse Retina

Mouse retina labeled with antibodies against red/green cone opsins (magenta) and rhodopsin (green).